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Analgesic mesotherapy

Mesotherapy, also called Intra Dermal Therapy (IDT), is a drug therapy consisting in the administration of minimal doses of drugs to a skin layer called dermis. It strictly takes place under medical expertise as it requires a diagnosis, an assessment of the treatment option compared with other therapeutic options, a pharmacological choice and the analysis of the results.


The merit of having the intuition and demonstrating the effectiveness of mesotherapy goes to a French physician, Dr. Michel Pistor, who unexpectedly found the disappearance of deafness in a patient who had been deaf for forty years with an intravenous injection of the drug procaine. At this point, Dr. Pistor had the brilliant idea of performing multiple subcutaneous injections of small quantities of procaine in the periauricular area instead of in a vein.
From that moment on, unexpected improvements began, such as the attenuation of symptoms such as tinnitus, vertigo, and pain in the temporomandibular joint.

Mesotherapy is performed by injecting very small doses of drugs with short needles into the subcutaneous tissue. The result is a subcutaneous deposit of the injected substance whose molecules directly affect the sites targeted by the treatment hence locally amplifying the therapeutic effects and limiting the general side-effects due to the small amounts of drug (2-4 ml depending on the extension of the anatomical part affected by the condition).Immediately after the injection, a “bump” appears indicating the build-up of a drug that will be released in the following days as if it were a “depot” formulation (or “slow release”). The bump looks like a small mosquito bite. It does not itch, it’s not painful and it lasts a few minutes. It is evidence of the correctness of the method.


The most common application of mesotherapy is for pain, inflammatory and degenerative disorders of the musculoskeletal system, such as inflammatory states of arthrosis, tendinitis, bursitis, lumbar disease, cervical pain, muscle-tense headaches, bruises and distortions.


Mesotherapy is particularly beneficial and useful when the age of patients and their general health conditions would advise against the use of oral medication hence reducing the overload for organs such as stomach, liver and kidneys. Particularly in rehabilitation, mesotherapy is beneficial because it accelerates functional recovery and enhances the effects of manual therapies and instrumental therapies such as laser, Tecar, shock waves and others.


The frequency of the therapy is usually weekly, but it may vary depending on the disease and its clinical (acute or chronic) phase from one every 4 days to one every 30 days. The number of sessions is variable, not exceeding, with most patients, six doses per cycle.

Although it is a low-invasive therapy and involves inoculation of small pharmacological quantities, mesotherapy is not indicated in allergic subjects with severe circulatory, cardiac and respiratory disorders as well as in pregnant women.